Human FOXP3+T regulatory cell heterogeneity
نویسندگان
چکیده
منابع مشابه
Human FOXP3+ T regulatory cell heterogeneity
FOXP3-expressing CD4+ T regulatory (Treg) cells are instrumental for the maintenance of self-tolerance. They are also involved in the prevention of allergy, allograft rejection, foetal rejection during pregnancy and of exaggerated immune response towards commensal pathogens in mucosal tissues. They can also prevent immune responses against tumors and promote tumor progression. FOXP3-expressing ...
متن کاملRegulatory T‐cell heterogeneity
Regulatory T cells (Tregs) preserve immune homeostasis by suppressing autoimmunity and inflammation. While most Tregs develop in the thymus, they are heterogenous in their tissue localisation and function. This heterogeneity is advantageous for the maintenance of immune and tissue homeostasis in organs such as gut and kidney but often detrimental in the context of tumor, since Treg cells can da...
متن کاملHuman lung mast cell heterogeneity.
What are the implications of these findings for the understanding of immune responses to respiratory viral infections in human disease? We know that, in the airways of infants with respiratory syn-cytial virus bronchiolitis, there is massive production of proinflammatory cyto-kines 8 9 and chemokines 10 11 and recruitment of inflammatory cells. 12 It is difficult in clinical studies which use b...
متن کاملRegulatory T-cell heterogeneity and the cancer immune response
The frequency of circulating or tumour-infiltrating regulatory T cells (Tregs) has been associated with poor patient survival in many cancers including breast, melanoma and lung. It has been hypothesised that Tregs impact the anti-tumour function of effector T cells, resulting in worse outcomes for patients. However, high infiltrates of Tregs have been associated with a positive outcome of pati...
متن کاملRegulatory Role of Cell Division Rules on Tissue Growth Heterogeneity
The coordination of cell division and cell expansion are critical to normal development of tissues. In plants, cell wall mechanics and the there from arising cell shapes and mechanical stresses can regulate cell division and cell expansion and thereby tissue growth and morphology. Limited by experimental accessibility it remains unknown how cell division and expansion cooperatively affect tissu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical & Translational Immunology
سال: 2018
ISSN: 2050-0068
DOI: 10.1002/cti2.1005